Present research work describes emulsion non solvent addition technique for microencapsulation of tinidazole using dichloromethane and cyclohexane as solvent and nonsolvent respectively. Liquid Paraffin was used as the liquid dispersion medium, tween 80 as an emulsifying agent. The process variables included variations in core: coat ratios. Microcapsules obtained were evaluated for flow properties, particle size, taste masking efficiency, drug content and in vitro release studies. Results of the study revealed that microcapsules obtained from 1: 2 ratio (core: coat) were spherical in shape with an average particle size of 343 microns. The encapsulation efficiency was found to be 75 ââ?¬â?? 85 % w/w depending on the stirring speed. Taste masking evaluation was done by time intensity method and it showed that taste of Tinidazole was masked successfully. Dissolution studies revealed that complete drug was released in 3 hrs. Thus, it can be concluded that effective taste masking of Tinidazole was achieved by microencapsulation technique using Eudragit RSPO polymer.
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